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Sildigra 250 mg, which contains sildenafil, should not be used with nitrates because combining the two can cause a dangerous drop in blood pressure. Nitrates, often used to treat angina (chest pain) and other heart conditions, work by relaxing blood vessels, which can lead to a significant decrease in blood pressure when used with sildenafil. This can result in symptoms like dizziness, lightheadedness, fainting, or even more severe cardiovascular complications. Sildigra 250mg important to inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements, to avoid harmful interactions. If you have any concerns about your medications or their interactions, it's best to consult with a healthcare professional for personalized advice.