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Sildalist Strong 140 mg is a medication that typically contains a combination of sildenafil and tadalafil. Both sildenafil and tadalafil are phosphodiesterase type 5 (PDE5) inhibitors, which means they work by increasing blood flow to certain areas of the body by relaxing smooth muscles and dilating blood vessels. Pulmonary vascular resistance (PVR) refers to the resistance in the blood vessels of the lungs. In conditions such as pulmonary arterial hypertension (PAH), PVR is elevated, leading to increased workload on the right side of the heart. By inhibiting PDE5, medications like Sildalist Strong 140mg can relax the smooth muscles in the pulmonary blood vessels, leading to vasodilation and a reduction in pulmonary vascular resistance. This effect can help improve blood flow through the lungs and reduce the workload on the right side of the heart, which can be beneficial in conditions associated with increased PVR, such as PAH. However, it's important to note that while sildenafil and tadalafil are approved for the treatment of PAH, the use of higher doses such as 140 mg may not be standard practice and should only be undertaken under the supervision of a qualified healthcare provider. Additionally, individual responses to medications can vary, so it's essential for patients to follow their healthcare provider's recommendations and undergo appropriate monitoring while taking these medications.